What to know about buprenorfina, who could help fight the opiate crisis?

When President Trump announced his intention to impose rates to Mexico and Canada, one of his declared rational ones was to force those countries to curb Fenanil’s flow in the United States. In the tax year 2024, the protection of customs and borders of the United States seized almost 22,000 pounds of pills, dust and other products containing Fenetanil, falling compared to 27,000 pounds in the previous tax year. More than 105,000 people died from overdose, three quarters of them from Fenetanil and other opioids, in 2023 cause fatal overdose.

In my article for the magazine, I notice that one of the many tragedies of the opiate epidemic is that a treatment proven for opiate addiction, a drug called buprenorfina, is available in the United States for more than two decades, but has been drastically subjected Indeed. Tens of thousands of lives could have been saved if it had been used more widely previously. In his actions and rhetoric, Trump seems to emphasize the reduction of the offer as a response to the crisis of the Fenanil. But the president of Mexico, Claudia Sheinbaum, indicated the American question as a driver of the problem. In fact, if quite opioid users in the United States ended up receiving buprenorphine and other effective drugs based on drugs, perhaps that question of illegal opioids such as Fenanil could be reduced.

A wealth of tests suggests that an approach based on drugs that uses buprenorphine-and itself a type of opioid-is much more effective in preventing deaths for overdose than approaches based on abstinence. (Methadone, a slightly more powerful opioid, is also effective as treatment.) That greater success derives in part from the fact that, involving the same receptors stimulated by Fenanil and other illegal opioids, buprenorphine (and methadone) can expand significantly The cravings and the withdrawal of symptoms. Numerous studies indicate that people who come out of programs based on abstinence must actually face a greater danger of overdose than when chronically used illegal opioids are used. After abstaining for a long time, the former users lose tolerance to opioids; The doses that were previously fine can become fatal. This is one of the reasons why many dependence experts think that a drug such as buprenorphine is more effective as a treatment for opiate use disorder than to stop cold turkey. It significantly reduces the cravings and misery that could cause an impact.

Although the United States government has partially financed the development of buprenorphine as a treatment for opiate addiction, France was one of the first countries to exploit its potential. In the 90s, the French health authorities began to allow all doctors to prescribe buprenorphine. At the beginning of the 2000s, the deaths from overdose there by heroin and other opioids had decreased by almost 80 %. Other European countries, such as Switzerland, which have made drugs for the treatment of easily accessible opioid use disorder also have much lower mortality rates for overdose than those observed in the United States.

Significantly entering the flow of Fenanil into a country as vast as the United States is difficult. Very small quantities are needed to provide the entire American demand – only 10 metric tons, based on an estimate. And those 10 metric tons, equal to the weight of a few cars, must be found among the over seven million trucks that cross the southern border every year.

Unlike the heroine, which derives from opium poppy, the Fenanil is entirely synthesized in the workshops. Without agriculture, its production does not depend on the ground, sun, water, fertilizers or large work; The right chemicals, a competent chemist and a laboratory are all that is necessary. The manufacturers of Fenestan-like those that produce methamphetamine, sedative xilazine, the stimulant caprogcts and other concoctions from what has been called “revolution of synthetic drugs”-so much less vulnerable to the types of direct contrast efforts, for example, to Example Coca farmers in South America. And they can recover from the setbacks much more quickly: when a drug expedition is seized, they must not wait for a new harvest to grow; If they have precursor chemicals, they can immediately manufacture more drugs.

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