How Science Went to Ruin (and Fall)

These early studies “highlighted both the potential we could learn from dogs and that we needed larger sample sizes to do it really well,” said Elinor Karlsson, a geneticist at UMass Chan Medical School and the Broad Institute. And so researchers began creating large citizen science projects, seeking DNA samples and data from dogs across the United States.

Pet owners have risen to the challenge. The Golden Retriever Lifetime Study, which began recruiting in 2012, has followed more than 3,000 dogs in an attempt to identify genetic and environmental risk factors for cancer, which is particularly common in the breed. Since 2019, the Dog Aging Project, a long-term study of health and longevity, has enrolled approximately 50,000 dogs.

Dr. Karlsson’s personal project, Darwin’s Dogs, numbers 44,000 canines and counting. (About 4,000 have had their genomes sequenced.) Researchers are mining the data for clues about bone cancer, compulsive behavior, and other traits. Among the early findings: Although many behavioral traits, such as sociability and trainability, are inherited, they are widely distributed across the canine kingdom, and breed is a poor predictor of an individual dog’s personality.

This spring, Dr. Karlsson unveiled a long-awaited expansion: Darwin's Cats. “I'm a total cat lover, I've never had a dog,” she said. Later, in an email, she added, “I'd like to know if 'the cat sleeps on your head' is influenced by genetics.”

These projects were made possible by faster and cheaper genomic sequencing. But the “tremendous enthusiasm” of pet owners was key, said Dr. Ostrander, who now leads the Dog10K project, an effort to build a comprehensive global catalog of canine genetic diversity.

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